Promethazine

Laboratory Report # 3.2 Title:         Promethazine 0.2% Syrup          pick up:                   learner Name: 1.         Describe the dispensing directions for the preparation:         A. Indication and pass judgment motion:                           Promethazine HCL is a powerful antihistamine drug utilize to track allergic conditions and,                  because of the sedative action, insomnia. It is also utilise as an anti-tussive in cough mixings.         Promethazine can be administered by emit or injection.         B. Directions/administration/use: Sig:         TAKE sensation teaspoonful OF SYRUP BY MOUTH AT MEALTIMES AND AT BEDTIME.         C. Precautions/DI: elapse medication out of r distributively of children Do non confuse alcohol w hile on this medication Contraindications: ·         children downstairs 2yrs ·         SC or intra-arterial injection ·         narrow-angle glaucoma ·         prostatic hypertrophy ·          vesica or pyeloduodenal obstruction ·         MAOI therapy ·         hypersensitivity to promethazine and other phenothiazines wayward Reactions: drowsiness dizziness ·         xerostomia ·          purposelesspyramidal reactions                  Drug Interactions: belladonna benztropine cabergoline cisapride dofetilide gatifloxacin grepafloxacin halofantrine levofloxacin atomic number 3 meperidine hydrochloride moxifloxacin orphenadrine pimozide porfimer procyclidine sotalol sparfloxacin tramadol trihexyphenidyl          D. Storage: Keep the syrup at manner temperature, away from heat, light, and moisture. Do not freeze.         E. dis! oriented paneling: Use your medicine as soon as you commend that you have missed your paneling. If it is nearly time for your future(a) dose, hold back until therefore to use the medicine and ignore the missed dose. You should not use two doses at whiz time. 2.         Purpose of each excipient used in the experiment: umber         -         flavoring mover Sucrose         -         sweetening instrument, suspending and viscosity-increasing agent. legato Glucose         -         to house calories, taste, and to improve cristal of atomic number 11                                    and water supply across the intestinal barrier through osmosis          Glycerin         -         used as a demulcent in cough preparations for soothing and protecting              Â Â Â Â Â          the mucous membranes and relieves irritation. When administered by                            backtalk or parenterally, glycerine increases the plasma osmolality,                           resulting in the movement of water by osmosis from the extra vascular                           spaces into the plasma. sodium Chloride-         electrolyte - source of sodium (Na+), used in combination with glucose for oral rehydration in shrewd diarrhea. Vanillin         -         flavoring/perfuming agent Sodium Benzoate         preservative with antibacterial and anti-fungal properties complete(a) Water         -         diluent 3.          come on your calculations and compounding (in steps):         Calculations: Prome thazine HCL         2 g      Â!  Â Â          x         (90mL / greenmL)         =         0.18 g Cocoa         180 g         x         (90mL / 1000mL)         =         16.

2 g Sucrose         600 g         x         (90mL / 1000mL)         =         54 g Liquid Glucose         180 g         x         (90mL / 1000mL)         =         16.2 g Glycerin         50 mL         x         (90mL / 1000mL)         =          4.5 mL x (1.25g/mL) = 5.625 g Sodium Chloride         2.0 g         x         (90mL / 1000mL)         =         0.18g sp. gravity Vanillin         0.2 g         x         (90mL / 1000mL)         =         0.018 g Sodium Benzoate         1.0 g         x         (90mL / 1000mL)         =         0.09 g P. Water         1000 mL         x         (90mL / 1000mL)         =         90 mL Ft. 90 mL         Promethazine:         (2 g / 1000 mL)         x 100 % = 0.2% syrup         1 Tsp = 5 mL x (0.2 % / 100 %) = 0.01 g x (1000 mg / 1 g) = 10 mg / dose Preparation: The sucrose and cocoa were merge together in a beaker. To this smorgas bord, the glucose, glycerin and vanillin were gradual! ly added. The sodium benzoate and sodium chloride were indeed dissolved in a undersize amount (30 mL) of warm water. The promethazine HCL was then added to the solution and was complex well. The contents were then transferred to the mixture in the beaker. The entire mixture was brought to a labour and the boiling temperature was maintained for 2 minutes. The mixture was allowed to cool to room temperature and the volume was brought up to 90 mL by adding superfluous pure water. If you want to get a full essay, rear it on our website: OrderEssay.net

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